C9ORF72 anticorps (AA 110-199)

N° du produit ABIN7539802

L’anticorps Souris Monoclonal anti-C9ORF72 a été validé pour ELISA, IHC et FACS. Il convient pour détecter C9ORF72 dans des échantillons de Humain et Rat.

Aperçu rapide pour C9ORF72 anticorps (AA 110-199) (ABIN7539802)

Antigène: C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp C9ORF72 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 4D5G1

Détail du produit anti-C9ORF72 anticorps

Épitope: AA 110-199

Fonction: C9orf72 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human C9orf72 (AA: 110-199) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur C9ORF72

Antigène: C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))

Autre désignation: C9orf72

Sujet: The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire: 54.3 kDa

UniProt: Q96LT7